Regulation of Cell Division Biology Diagrams Three G 0 states exist and can be categorized as either reversible or irreversible (senescent and differentiated).Each of these three states can be entered from the G 1 phase before the cell commits to the next round of the cell cycle. Quiescence refers to a reversible G 0 state where subpopulations of cells reside in a 'quiescent' state before entering the cell cycle after activation in
Historically, the G0 phase of the cell cycle was referred to as an inactive, non-cycling state. It was first recognized and described as a state in which cells have irreversibly exited the cell cycle, Quiescence is also a state of growth cessation that occurs in multicellular organisms. Tumour proliferation is one of the main hallmarks of cancer development [] and has been extensively studied.While most of the cells within the tumour have a high proliferative capacity, occasionally under stress conditions, some cells will become arrested temporarily in the G0 phase of the cell cycle, in a reversible state often referred to as 'quiescence', 'dormancy', 'diapause-like
What is Quiescence? Biology Diagrams
For most quiescent cells, this arrest takes place in G0, a resting phase outside of the cell cycle that occurs prior to S phase, Heldt FS, Butera F, Stoy H, Mansfeld J, Novak B, and Bakal C (2017). DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun 8, 14728.
The capacity of cells to re-enter the G1 phase of the cell cycle from the G0 phase is a distinguishing feature of quiescence. Unlike quiescence, in which cell cycle arrest is reversible, terminal differentiation involves regeneration via cell differentiation from stem cells while remaining in the G0 phase (Hernandez-Segura, Nehme, & Demaria
Cell Cycle G0 Phase - an overview Biology Diagrams
Explore the G0 phase of the cell cycle, its role in tissue maintenance, and how cells transition back to active phases. G0 allows prolonged quiescence, reducing unnecessary cell division risks that could lead to pathology. This state conserves energy and ensures differentiated functions are preserved, supporting tissue integrity and function.