Figures and data in Aurora kinase A localises to mitochondria to Biology Diagrams For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review we discuss the biology of these kinases: structure, function, regulation and association with cancer. Methods and results: A literature search. Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their Abstract. Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function Aurora A is localized to spindle poles where it provides spatial information for spindle functions in prometaphase. Aurora A is a kinase that is highly related to Aurora B but the two kinases localize to distinct subcellular regions during mitosis . From prometaphase to anaphase Aurora A localizes to the two poles of the spindle, which are the
Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution.
Roles of Aurora Kinases in Mitosis and Tumorigenesis Biology Diagrams
These inhibitors obstruct Aurora kinases, which in turn leads to aberrant mitosis. As a result, the p53-dependent checkpoint is activated and results in the induction of a G1-like cell-cycle arrest. Several small-molecule inhibitors of Aurora kinases, such as VX-680, PHA-739358 and AZD-1152, have shown anti-cancer effects in preclinical and
As described above, there are three classes of aurora kinases in multicellular organisms, including humans: Aurora A (a.k.a. Aurora 2) functions during prophase of mitosis and is required for correct duplication and separation of the centrosomes (the microtubule organising centres in eukaryotic cells). Aurora A activity is positively-regulated by the spindle protein TPX2, [4] [5] and has The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly Abstract. Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially the process of chromosomal segregation. Besides regulating mitosis, Aurora kinases have been implicated in regulating meiosis.
Roles of Aurora Kinases in Mitosis and Tumorigenesis Biology Diagrams
During mitosis, Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore. They also regulate signalling by
